DIAMOND

Advances in nucleic acid therapeutics
Nucleic acid therapeutics are changing healthcare by delivering promising drugs that use new technologies and modes of action to treat disease. Several of these innovative medicines are being utilized to treat infectious diseases, protein and gene deficiencies, and many types of cancers. With more and more effort and resources being directed into this area, we may only be at the beginning stages of a revolution in medicine.

Solutions for nucleic acid therapeutic development
There are two classes of nucleic acid therapeutics: mRNA-based therapeutics or vaccines and synthetic oligonucleotide therapeutics. Learn more below about the products and technologies you’ll need as you make critical choices to successfully develop and manufacture these revolutionary

mRNA-based therapeutics and vaccines
mRNA based therapeutics and vaccines are produced biosynthetically using nucleotides, enzymes, and mRNA modification systems.

Synthetic oligonucleotide therapeutics
Synthetic oligonucleotide therapeutics are produced chemically using DNA or RNA phosphoramidites

GOLD

As a global leader in analytical laboratory technologies, Agilent provides trusted answers to our customers’ most critical questions and challenges. Using more than 50 years of laboratory, clinical, and enterprise-level expertise, we produce advanced instruments, software, and consumables, supported by teams of highly skilled and knowledgeable people.
For the pharmaceutical and biopharmaceutical industries, Agilent provides end-to-end workflows from research and drug discovery, to development, manufacturing, and quality control. We strive to provide reliable answers to help overcome analytical challenges and optimize the productivity needs of labs. Complete solutions to help get products to market faster.

GOLD

AmbioPharm, Inc. is a full-service peptide manufacturing company headquartered at our North Augusta, South Carolina, USA cGMP production site. Our second cGMP facility in Shanghai, China, performs process development & optimization, and manufactures building blocks, raw materials, and custom peptides at very large scale. Both cGMP facilities are capable of handling any manufacturing scale required to produce bulk peptides to custom specifications using a wide range of skill sets in both solid and solution-phase chemistry. Our management team has over 100 years cumulative experience running pilot to commercial scale production. We also perform organic conjugations to small molecules, proteins, toxoids, antifungals, KLH, and PEG.

GOLD

World leader in microanalytical instrumentation, CAMECA presents the NanoSIMS-HR, successor of the world-acclaimed NanoSIMS 50/50L Secondary Ion Mass Spectrometer series which have contributed to major advances in life sciences. Cryogenic compatible and offering unprecedented 30 nm lateral resolution imaging capabilities, the NanoSIMS-HR enables the detection and quantification of isotopically labeled biomolecules within cells, organs, and tissues. It measures cell metabolism activity, lipid uptake, endocytosis, etc, opening new horizons in biomedicine. Providing accurate determination of drug exposures at sub-cellular and organelle level, it supports the discovery of novel therapeutics such as NATs and ASOs.

GOLD

From complicated separations for drug development and crop-to-table processing solutions to enabling protein-rich diets and innovative healthcare solutions, DuPont´s broad range of Life Science products improve the quality of life for humans, plants, and animals in our world. As a global market leader in adsorbents, chromatography resins, and ion exchange resins, DuPont Water Solutions offers a broad range of products designed for use in bioprocessing and drug synthesis. Whether it’s new advanced gene therapies or a conventional small molecule drug, DuPont has a wide range of polymeric purification resins to fit a multitude of applications. With a wellness optimized world at our core, our global research and development capabilities can address purification challenges in drug and diagnostics manufacturing now and in the future, resulting in better outcomes for patients and life science companies alike.

GOLD

EUROAPI is focused on reinventing active ingredient solutions to sustainably meet customers’ and patients’ needs around the world. We are a leading player in active pharmaceutical ingredients with approximately 200 products in our portfolio, offering a large span of technologies while developing innovative molecules through our Contract Development and Manufacturing Organization (CDMO) activities.
Taking action for health by enabling access to essential therapies inspires our 3,450 people every day. With strong research and development capabilities and six manufacturing sites, all located in Europe, EUROAPI ensures API manufacturing of the highest quality to supply customers in more than 80 countries. Find out more at www.euroapi.com and follow us on LinkedIn.

GOLD

PolyPeptide Group AG and its consolidated subsidiaries (“PolyPeptide”) is a focused Contract Development & Manufacturing Organization (CDMO) for peptide- and oligonucleotide-based active pharmaceutical ingredients. By supporting its customers mainly in pharma and biotech, it contributes to the health of millions of patients across the world. PolyPeptide offers products and services from pre-clinical through to commercial stages, including generics. Its active custom projects pipeline reflects the opportunities from novel drug therapies in development to fight both widespread and rare diseases. Dating back to 1952, PolyPeptide today runs a global network of six cGMP-certified facilities in Europe, the U.S. and India. PolyPeptide Group AG’s shares (SIX: PPGN) are listed on SIX Swiss Exchange.

GOLD

Sinopep is a leading player in the therapeutic peptide industry. Our proprietary technology has revolutionized large-scale manufacturing for complex peptide drugs. This gives us among the highest yields, purities and batch sizes ever reported. As the obesity-drug market grows rapidly, Sinopep is positioned to meet the huge demands for pure, low-cost peptides. Aside from CMO services, Sinopep also excels in providing high-quality end-to-end CDMO services encompassing multiple modalities such as oligonucleotides, small molecules, and synthetic conjugates. It makes Sinopep one of the most trusted worldwide partners in the pharmaceutical and healthcare industries.

GOLD

Tosoh Bioscience is an acknowledged global leader in liquid chromatography with a focus on bioseparations. Our chromatography experts enable our biopharma partners to provide safe and efficient therapies against life-threatening diseases.

We offer a comprehensive line of chromatography instrumentation, media and (U)HPLC columns. These are used from R&D to manufacturing to characterize and purify therapeutic peptides, proteins and oligonucleotides at lab, pilot, and commercial scale.

Tosoh Bioscience is part of the Tosoh Group, a Japanese chemical and specialty products group with over 100 companies worldwide and a workforce of about 13000 people.

SILVER

For over 20 years, Asymchem has been positioned and structured to act as a true partner for pharmaceutical and biotech companies world-wide by offering integrated solutions across all stages of drug development and into commercialization. Our oligonucleotide solutions provide clients with full services in drug substance, from process development through GMP manufacturing, and drug product, from preformulation development through fill-finish. Asymchem’s Chemical Macromolecule Division (CMMD) can support traditional peptides, pseudopeptides, peptide+linker, peptide-drug conjugates, polymer-drug conjugates, and other highly active peptide molecules. 

SILVER

Asymchem is a leading global CDMO known for its integrated offerings throughout the entire drug development lifecycle. From early-stage research to commercialization, we provide a tailored suite of services that cater to the specific needs of each project.
We are committed to embracing cutting-edge technologies that not only enhance efficiency and safety but also prioritize sustainability in the development and manufacturing process. This translates to smarter, greener, and more cost-effective solutions for our clients, ultimately speeding up the delivery of life-saving medications to patients.

SILVER

Axolabs is a leading custom research organisation providing high-end solutions and consultancy in the field of oligonucleotide therapeutics and nucleic acid medicines. Founded firmly on our world-leading know-how with more than 20 years of experience, we provide high-end preclinical and clinical development solutions tailored to our client’s needs.

As a one-stop-shop we provide efficient and validated services towards the successful development of oligonucleotide-based therapeutics. We deliver integrated solutions for preclinical research and clinical development covering chemistry, biology, bio-analytics, analytics and manufacturing, including manufacturing capabilities for oligonucleotide drug substance under the standards of GMP at our branches in Petaluma and Berlin.

SILVER

BioSpring is a world leading contract manufacturing organization (CMO) for synthetic nucleic acids in the field of oligonucleotide-based commercial therapies, clinical therapeutic development, as well as diagnostics and R&D.
Since 1997, BioSpring provides high-quality products and services under cGMP to the pharmaceutical and biotech industry worldwide.
Located in Frankfurt, Germany, BioSpring’s cGMP-certified and FDA/EMA-inspected facilities offer manufacturing capacity of multiple hundred kilograms per year, including dedicated commercial manufacturing suits and state-of-the art commercial analytical laboratories.
Driven by technology and science, BioSpring’s team is developing innovative manufacturing processes and (bio)-analytical methods to contribute to the future of health in the field of oligonucleotide-based therapies, vaccines, and diagnostics.

SILVER

Critical Raw Materials and Services for Diagnostics, Vaccines and Pharmaceuticals – where Chemistry meets Biology and Products meet Services, Biosynth is at the Edge of Innovation.

With an unrivalled research product portfolio and end-to-end manufacturing services, we are science led and customer focused to solve problems and deliver key reagents across Complex Chemicals, Peptides and Key Biologics all from one trusted partner.

SILVER

Biotage is a Global Impact Tech Company committed to solving society’s problems. We offer workflow solutions and products to customers in drug discovery and development, analytical testing and water and environmental testing. Biotage is contributing to sustainable science with the goal to make the world healthier, greener and cleaner – HumanKind Unlimited. Our customers span a broad range of market segments including pharmaceutical, biotech, contract research and contract manufacturers.

SILVER

CEM was founded in 1978 by our current CEO, Dr. Michael J. Collins. For over 40 years we have designed and developed laboratory instrumentation and scientific methods (both microwave-based and non-microwave technologies) that are used by major companies, prestigious research institutes, and universities around the world. We are a private company with global headquarters outside Charlotte, North Carolina, along with offices in England, Germany, Japan, France, Italy, Singapore, and Ireland.

Committed to the continuous advancement of solid-phase peptide synthesis, our goal is to develop the most effective and efficient SPPS workflow solutions for the peptide and peptidomimetic community.
Our performance- and efficiency-driven peptide synthesizer lines are available in both sequential and parallel formats, spanning research through production scale synthesis. We offer a suite of high-quality SPPS chemicals, including preloaded resins and amino acids in both bulk and conveniently pre-weighed options. Our powerful purification system streamlines peptide isolation, simplifying the transition from analytical to preparative scale.
From reagent preparation and peptide synthesis to cleavage and purification, our dedicated team of scientists and engineers strive to simplify science, start to finish.

SILVER

ChemGenes, an ISO 9001 certified company established in 1981, is the industry leader in manufacturing oligonucleotide synthesis reagents and has consistently provided the highest quality phosphoramidites and solid supports in the market. Our facility, just outside of Boston/Cambridge Massachusetts USA, is setup for bulk manufacturing of therapeutic grade phosphoramidite and solid support DNA/RNA synthesis products for GMP grade oligonucleotide manufacturing. ChemGenes carries the widest variety of modified phosphoramidites and supports currently used in oligonucleotide synthesis including Microarray Technology, Oligonucleotide Therapeutics, Oligonucleotide Based Probes and other areas of Nucleic Acid research. In addition, ChemGenes is expanding its custom oligonucleotide synthesis department specializing in the manufacture of ASOs, siRNA, gRNA, gapmers, aptamers, DNA based probes, and superior quality beads for Single Cell mRNA sequencing applications using Drop-Seq, Slide-seq, and Seq-Well methods. ChemGenes remains devoted to providing you with invaluable customer service and comprehensive technical support.

SILVER

Eurogentec is an international company founded in 1985 and part of Kaneka Corp. since 2010.

Eurogentec is recognized as one of the major suppliers in the field of genomics (Oligonucleotides, qPCR kits & reagents) and proteomics (Custom & catalog antibodies and peptides) as well as a trusted Contract Development and Manufacturing Organization (CDMO) for the production process development and manufacturing of vaccines and medicines (therapeutic oligonucleotides, GMP plasmids, GMP recombinant proteins, mRNA…).

Eurogentec provides products and services to scientists involved in the life science research, molecular diagnostics and therapeutic development.

SILVER

Gilson, leader in fluidics, purification and sample management, manufactures since 1957 instrumentation and software enabling customers to purify and manipulate their samples. Our offer includes automated liquid handling products from Prep HPLC, SPE, and GPC Clean-up to our manual liquid handling products, as the world’s first adjustable volume pipette, PIPETMAN®.

SILVER

Gyros Protein Technologies provides enabling peptide synthesis and bioanalytical solutions, helping scientists in research through bioprocess applications. Our peptide synthesizers PurePep® Chorus, Symphony® X, PurePep® Sonata®+, and chemistries deliver uncompromising purity, flexibility and quality in less time. Sensitive, accurate and robust nanoliter-scale immunoassays for pharmacokinetics/pharmacodynamics, immunogenicity and quantitating bioprocess impurities are performed on our proprietary platforms Gyrolab® xPand and Gyrolab xPlore™. Peptide synthesis and bioanalytical solutions: accelerate your discovery, development and manufacturing of safer biotherapeutics. Gyros Protein Technologies is part of the Biopharmaceutical Division of Mesa Laboratories, Inc.

SILVER

Jiuzhou Pharmaceutical Co., Ltd., situated in Taizhou, Zhejiang, is recognized as a premier CDMO, renowned for its innovation and technical prowess. The company champions sustainable, environmentally friendly technologies in the pharmaceutical sector, employing advanced techniques like chiral and asymmetric synthesis, and state-of-the-art fluorination to enhance drug efficacy and stability. Adhering to its principle, “Serve life, guard health," Jiuzhou Pharma offers a one-stop service, effectively managing over 900 global clients from discovery through to commercialization. This includes stringent intellectual property protections and a focus on advanced chemical synthesis and manufacturing technologies. As a technical and ethical leader, Jiuzhou Pharma continually sets benchmarks for quality, innovation, and environmental stewardship in pharmaceutical development.

SILVER

In 1989, Microsynth pioneered the availability of DNA oligonucleotides to the broader scientific community, catalyzing scientific research and pharmaceutical discovery. More than thirty years on, we are a leading manufacturer of oligonucleotide products, including those for diagnostic applications. In particular, over the past decade, Microsynth has also gained the reputation of being an innovative supplier of therapeutic siRNA and ASO products.
On top of our broad expertise in oligonucleotide synthesis, Microsynth offers comprehensive DNA and RNA analysis services. These services include Sanger and NGS sequencing, DNA/RNA isolation, PCR assays, and contract research.

SILVER

Established in 1988, Milestone is headquartered in Italy with R&D and manufacturing centre in Switzerland and offices in the United States, China, Japan and Korea. Milestone’s mission is to offer the most advanced instrumentation to address post-synthesis challenges in oligonucleotides production. Our industry-leading technology, in combination with fast and responsive service and application support, allows Milestone to achieve our goal of giving you the highest return on investment possible.

SILVER

Established in 1984, Neuland Laboratories is an end-to-end solutions provider for the pharmaceutical industry’s chemistry needs as a leading manufacturer of active pharmaceutical ingredients (APIs). Supported by three world-class US FDA and EU GMP compliant manufacturing facilities and complex chemistry capabilities, Neuland has become a trusted partner for innovators as well as generics.

Our Custom Manufacturing Solutions span the full range of the pharmaceutical industry’s chemistry requirements, from pre-IND through commercial manufacturing. We offer both small-scale clinical trial quantities and full commercial-scale supply with minimal tech transfer timelines. Our R&D facility is approved by the Department of Scientific and Industrial Research and inspected by the USFDA without any observations. The facility houses development labs, analytical labs, a kilo lab for scale-up and dedicated lab for peptides.

The company is headquartered in Hyderabad, India and the manufacturing and research facilities are situated near Hyderabad. Neuland is reliable manufacturing and development partner to customers in over 80 countries across US, Europe, Japan, APAC, India, MENA and LATAM.

SILVER

PeptiSystems AB develops instruments for peptides and oligonucleotides synthesis. Utilizing the flowthrough solid phase synthesis, they are designed to significantly reduce solvent and reagents consumption, shorten synthesis time and improve synthesis control, purity and yield. They are used for gram to kilogram syntheses offering easy scale-up from research to production.

SILVER

Quality Assistance is a leading European Contract Research Organisation providing the pharmaceutical industry with all the analytical services required by EMA and FDA regulations for the development and marketing of innovative human medicinal products.

With more than 40 years’ experience, Quality Assistance holds a unique position on the market with all its laboratories on one site and 250 highly qualified professionals.

We assist our clients from candidate selection, through non-clinical and clinical studies, to marketing authorisation, using our state-of-the-art, product-dedicated expertise in analytical sciences.

SILVER

Founded in 2003 near Cambridge, UK, Vapourtec is a leading manufacturer of laboratory-scale flow chemistry instruments. Their R-Series and E-Series systems, along with fast-flow peptide synthesizers, empower chemists globally. With over 750 installations and 1,000 citations, Vapourtec’s innovative products revolutionise scientific research and chemical manufacturing worldwide.

SILVER

WuXi TIDES, a unique Contract Research and Development Manufacturing Organization (CRDMO) platform, is an integral part of WuXi AppTec. WuXi TIDES offers our worldwide partners efficient, flexible, and high-quality solutions for the drug development of oligonucleotides, peptides and related synthetic conjugates (“TIDES” drugs). We greatly simplify the TIDES drug development by providing all discovery, CMC development and the entire manufacturing supply chain under one roof.

IN COLLABORATION WITH

The University of Barcelona is the most formidable public institution of higher education in Catalonia, catering to the needs of the greatest number of students and delivering the broadest and most comprehensive offering in higher educational courses. The UB is also the principal centre of university research in Spain and has become a European benchmark for research activity, both in terms of the number of research programmes it conducts and the excellence these have achieved.
Its own history closely tied to the history of Barcelona and of Catalonia, our university combines the values of tradition with its position as an institution dedicated to innovation and teaching excellence: a university that is as outward-looking and cosmopolitan as the city from which it takes its name.

IN COLLABORATION WITH

The University of Milan, founded in 1924, is a public institution that has a proactive role in science, technology and economics networks. It was one LERU co-founders and is the only Italian University to be a member of the organisation. The University of Milan is involved in several national and international research programs and has also strengthened its efforts to promote technology transfer, a growth area offering exciting new changes and challenges. The results of its research, attested to by an important quantity of scientific publications, have allowed it to obtain the top positions in the most authoritative international rankings. The research at the Department of Pharmaceutical Sciences covers a range of activities focused on the design, synthesis, development, and control of novel biologically active molecules, and of new pharmaceutical drug delivery systems, food supplements, cosmetics, biocides and medical devices. The goals are those of improving knowledge in the field of basic research, a major cultural investment to design a qualified research aimed at the discovery of novel drugs and able to boost an efficient technology transfer.

IN COLLABORATION WITH

The Department of Chemistry “Giacomo Ciamician" is within the University a community of over 100 researchers who, thanks to the high skills in all areas of chemistry, has the mission of creating scientific culture through basic and applied research, its promotion and diffusion both through didactic activities and with a strong relationship of comparison and exchange with society and the business world.

The Department has a long tradition of excellence in teaching, research and technology transfer in all sectors of the Chemical Sciences.